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基本信息

姓名:管吉松
院系:清华大学生命科学学院
职称:研究员
办公地址:清华大学医学楼D206
办公电话:010-62785905
电子邮箱:jsguan@mail.tsinghua.edu.cn

教育经历

1997/09 – 2001/07  南京大学 生物化学 学士
2001/09-2006/07 中科院上海生命科学研究院神经科学研究所 神经生物学 博士
2006/11-2010/12 美国麻省理工学院Picower学习记忆研究所 神经生物学 博士后

工作经历

2006 – 2010 美国麻省理工学院Picower学习记忆研究所 博士后研究员
2011 至今 清华大学生命科学学院 研究员 博士生导师
2011 至今 生命科学联合中心 研究员 博士生导师

研究方向

学习记忆的神经生物学机制,神经环路,神经计算

获得荣誉

2005 谈家桢基金九源奖学金一等奖
2006 中国科学院优秀博士论文
2015 北京市科技新星
2015 中国“万人计划”青年拔尖人才

代表性论文

1. Hong Xie, Yu Liu, Youzhi Zhu, Xinlu Ding, Yuhao Yang, Ji-Song Guan#. In vivo imaging of immediate early gene expression reveals layer-specific memory traces in the mammalian brain. Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2788-93.

2. Seo, J., Giusti-Rodriguez, P., Zhou, Y., Rudenko, A., Cho, S., Ota, K.T., Park, C., Patzke, H., Madabhushi, R., Pan, L. Mungenast AE, Guan JS, Delalle I, Tsai LH. Activity-Dependent p25 Generation Regulates Synaptic Plasticity and Abeta-Induced Cognitive Impairment. Cell. 2014 Apr 10;157(2):486-98.

3. Hong Xie, JiSong Guan, Laura A. Borrelli, Jing Xu, Alberto Serrano-Pozo, and Brian J. Bacskai, Mitochondrial Alterations near Amyloid Plaques in an Alzheimer’s Disease Mouse Model. J. Neuroscience, 2013, 33(43):17042-17051

4. Zhang J, Cao Q, Li S, Lu X, Zhao Y, Guan JS, Chen JC, Wu Q, Chen GQ.3-hydroxybutyrate methyl ester as a potential drug against Alzheimer’s disease via mitochondria protection mechanism. Biomaterials. 2013 Oct;34(30):7552-62.

5. Fass DM, Reis SA, Ghosh B, Hennig KM, Joseph NF, Zhao WN, Nieland TJ, Guan JS, Kuhnle CE, Tang W, Barker DD, Mazitschek R, Schreiber SL, Tsai LH, Haggarty SJ. Crebinostat: a novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity. Neuropharmacology. 2013 Jan;64:81-96.

6. Gräff J, Rei D, Guan JS, Wang WY, Seo J, Hennig KM, Nieland TJ, Fass DM, Kao PF, Kahn M, Su SC, Samiei A, Joseph N, Haggarty SJ, Delalle I, Tsai LH. An epigenetic blockade of cognitive functions in the neurodegenerating brain. Nature. 2012 Feb 29;483(7388):222-6.
7. Guan JS*, Su SC*, Gao J, Joseph N, Xie Z, Zhou Y, Durak O, Zhang L, Zhu JJ, Clauser KR, Carr SA, Tsai LH. Cdk5 Is Required for Memory Function and Hippocampal Plasticity via the cAMP Signaling Pathway. PLoS One. 2011; 6(9): e25735.  Epub 2011 Sep 30.

8. Shao-Qiu He*, Zhen-Ning Zhang*, Ji-Song Guan*, Hong-Rui Liu, Bo Zhao, Hai-Bo Wang, Qian Li, Hong Yang, Jie Luo, Zi-Yan Li, Lan Bao & Xu Zhang. Facilitation of μ-Opioid Receptor Activity by Preventing δ-Opioid Receptor-Mediated Co-Degradation. Neuron, 2011

9. Jun Gao*, Wen-Yuan Wang*, Ying-Wei Mao, Johannes Gra¨ff, Ji-Song Guan, Ling Pan, Gloria Mak, Dohoon Kim, Susan C. Su & Li-Huei Tsai. A novel pathway regulates memory and plasticity via SIRT1 and miR-134. Nature, 466(7310):1105-9 2010

10. Ji-Song Guan*, Stephen J. Haggarty*, Emanuela Giacometti*, Jan-Hermen Dannenberg*, Nadine Joseph, Jun Gao, Thomas J.F. Nieland, Ying Zhou, Xinyu Wang, Ralph Mazitschek, James E. Bradner, Ronald A. DePinho, Rudolf Jaenisch, Li-Huei Tsai. HDAC2 negatively regulates memory formation and synaptic plasticity. Nature 459(7243): 55-60; May 2009 (full research article)

11. Dohoon Kim, Christopher L. Frank, Matthew M. Dobbin, Rachel K. Tsunemoto, Weihong Tu, Peter L. Peng, Ji-Song Guan, Byung-Hoon Lee, Lily Y. Moy, Paola Giusti, Nisha Broodie, Ralph Mazitschek, Ivanna Delalle, Stephen J. Haggarty, Rachael L. Neve, YouMing Lu and Li-Huei Tsai. Deregulation of HDAC1 by p25/Cdk5 in Neurotoxicity. Neuron 60(5):803-17; Dec 2008

12. Hai-Bo Wang, Ji-Song Guan, Lan Bao and Xu Zhang. Distinct Subcellular Distribution of δ-Opioid Receptor Fused with Various Tags in PC12 Cells. Neurochemical Research, 33(10):2028-34 Oct 2008

13. Ji-Song Guan*, Zhen-Zhong Xu*, Hua Gao, Shao-Qiu He, Guo-Qiang Ma, Tao Sun, Li-Hua Wang, Zhen-Ning Zhang, Isabelle Lena, Ian Kitchen, Robert Elde, Andreas Zimmer, Cheng He, Gang Pei, Lan Bao and Xu Zhang. Interaction with Vesicle Luminal Protachykinin Regulates Surface Expression of δ-Opioid Receptors and Opioid Analgesia.  Cell 122: 619-631, 2005

14. Lan Bao*, Shan-Xue Jin*, Chen Zhang*, Li-Hua Wang, Zhen-Zhong Xu, Fang-Xiong Zhang, Lie-Chen Wang, Feng-Shou Ning, Hai-Jiang Cai, Ji-Song Guan, Hua-Sheng Xiao, Zhi-Qing D. Xu, Cheng He, Tomas Hökfelt, Zhuan Zhou, and Xu Zhang. Activation of Delta Opioid Receptors Induces Receptor Insertion and Neuropeptide Secretion. Neuron 37, 121-133,2003

15. Xu Zhang, Lan Bao, Ji-Song Guan. Role of delivery and trafficking of δ-opioid receptors in opioid analgesia and tolerance. Trends in pharmacological sciences , 27 (6): 324-329 JUN 2006 (Review)


• 2017年2月19日编辑

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